Antischistosomal impact of Albendazole and Nitazode on Schistosoma mansoni larval stages
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Antischistosomal Activity of Trioxaquines: In Vivo Efficacy and Mechanism of Action on Schistosoma mansoni
Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid molecules are highly active on the larval forms of the worms and exhibit different modes of action...
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The schistosomicidal properties of Nigella sativa seeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work we also studied the effects of crushed seeds on some antioxidant enzymes; which...
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Current schistosomiasis control strategies are largely based on chemotherapeutic agents and a limited number of drugs are available today. Praziquantel (PZQ) is the only drug currently used in schistosomiasis control programs. Unfortunately, this drug shows poor efficacy in patients during the earliest infection phases. The effects of PZQ appear to operate on the voltage-operated Ca2+ channels,...
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Aim: Schistosoma mansoni is a parasite of medical importance because it is the causative agent of intestinal schistosomiasis. The present study was designed to assess the in vivo antischistosomal effects of methanolic extracts of three food plants: Apple (Malus domestica), Lemon (Citrus limon) Original Research Article Muema et al.; EJMP, 9(1): 1-11, 2015; Article no.EJMP.16953 2 and Onion (All...
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ژورنال
عنوان ژورنال: African Journal of Microbiology Research
سال: 2015
ISSN: 1996-0808
DOI: 10.5897/ajmr2014.7214